Abstract
Trodusquemine is an aminosterol which has been proposed as a potential drug against Parkinson's and Alzheimer's diseases. It has been shown to reduce the toxicity of α-synuclein and Aβ oligomers in neuroblastoma cells. To further elucidate its mechanism of action, we have studied the effects of trodusquemine on biomimetic membranes. In particular, we have used atomic force microscopy to investigate the morphological and mechanical properties of supported lipid bilayers, mimicking neuronal membranes, in the absence and in the presence of trodusquemine.
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