Abstract
To the Editor: Previous studies have revealed the association between inflammation, atherosclerosis and cardiovascular diseases (CVD).1–3 Several recent investigations have addressed the involvement of pathological intimal thickening after macrophage infiltration and circulating apoptotic progenitor cells with telomere repeat-binding factor TRF2 in early atherosclerosis and prediction of carotid recurrent stenosis using intraplaque hemorrhage.4–7 The ultimate mechanism of atherogenesis and recurrent stenosis remains unclarified. In a previous study, we demonstrated vascular remodeling with inflammatory cells (monocytes/macrophages) infiltration in cerebral arteries of hypertensive rats.8 Our study attempted to elucidate the vascular changes leading to atherosclerosis, and to propose the predictive factor for restenosis. Five-week-old male spontaneously hypertensive rats (SHR) were obtained from National Animal Center. They were fed with standard rat chow and tap water, and kept in animal room with …
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