Abstract
Electrical phenomena located within the plasma membrane of the mammalian cardiac cells are connected with the cells’ main physiological functions—signals processing and contractility. They were extensively studied and described mathematically in so-called Hodgkin–Huxley paradigm. One of the physiological parameters, namely cell electric capacitance, has not been analyzed in-depth. The aim of the study was to validate the mechanistic model describing the capacitive properties of cells, based on a collected experimental dataset which describes the electric capacitance of human ventricular myocytes. The gathered data was further utilized for developing an empirical correlation between a healthy individual’s age and cardiomyocyte electric capacitance.
Highlights
Electrical phenomena located within the plasma membrane of the mammalian cardiac cells are connected with the cell’sK
The main aim of the study was to verify the predictive quality of the previously established correlation, combining healthy individuals’ age and cardiomyocyte volume/area/ electric capacitance, with the use of the collected and analyzed data describing the electric capacitance of human ventricular myocytes
Information describing age is presented in years [years] and electric capacitance is described in picofarads [pF]
Summary
K. Fijorek Department of Statistics, Faculty of Management, Cracow University of Economics, Rakowicka 27 Str., 31-510 Cracow, Poland main physiological functions—signals processing and contractility. The first area, namely electrical activity has been studied and described in the form of an equation derived by Hodgkin and Huxley [Eq 1] which is described as the H-H paradigm [1]. This paradigm is extensively used as a base for multiple models describing heart cells’ electric activity [2,3,4].
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