Inter-Fractional Variations in Volume and Radiation Dose to the Organs at Risk, High-Risk Clinical Target Volume and Implication of Image-Guided Adaptive Planning During Intracavitary Brachytherapy of Carcinoma Cervix.

Abstract

BackgroundGeometrical and anatomical variations occur during the brachytherapy of carcinoma cervix and dose optimization is necessary for every fraction of high‑dose rate intracavitary brachytherapy (HDR-ICBT) for carcinoma of the cervix. A single planned treatment is usually delivered for multiple fractions without consideration of inter-fractional applicator positioning variations and organ motion, which may lead to substantial differences between the planned and delivered doses. Aim and objectivesThis study was aimed at evaluating the inter-fractional variation in volume and radiation dose to organs at risk during ICBT for cervical cancer. Furthermore, the doses to high-risk clinical target volume (HRCTV) and the role of adaptive planning in ICBT were assessed.Materials and methodsTwenty-two patients with carcinoma of the cervix Stage IB2-IVA receiving ICBT were enrolled in the study. All the patients were treated with ICBT four fractions in two applications. For the first application, magnetic resonance imaging-based planning was done, and for the next three fractions, computed tomography (CT) scans were done before every treatment fraction. The CT images were contoured and replanned by keeping the First (I) fraction of each application as the reference. Dose-volume histograms (DVH) were generated, and details of D2cc (DVH on a volume of 2cc) of bladder, rectum, and sigmoid colon (organs at risk-OAR) and D90 HRCTV (dose covering 90%) were documented.ResultsIn patients receiving ICBT, variations in OAR D2cc ranged from 1.5 to 2.5Gy for the bladder (p- 0.001), from 2.0 to 3.2Gy (p-0.005) for the rectum and from 1.5 to 3.5Gy for the sigmoid colon (p 0.103). The p-value was significant for D2cc when compared with the OAR volume for the bladder and rectum in both applications, whereas it was not significant for the sigmoid colon. The percentage change in HRCTV coverage was 7% in the first application and by 16% in the second application because of adaptive planning.ConclusionSignificant variations in doses received by D2cc of the bladder and rectum as well as significant improvement in HRCTV coverage between the fractions were observed because of replanning. Hence, image-guided HDR-ICBT should be incorporated with adaptive planning when delivering in multiple fractions.