Abstract
This work represents modeling of electrical properties of pacemaker (sinus) cardiac cells. Special attention is paid to electrical potential arising from transmembrane current of Na+, K+ and Ca2+ ions. This potential is calculated using the NaCaX model. In this respect, molar concentration of ions in the intercellular space which is calculated on the basis of the GENTEX model is essential. Combined use of two different models allows referring this approach to integrative modeling.
Highlights
The cardiac muscle comprises typical and atypical pacemaker cardiac cells which form the cardiac conduction system
There is a need to develop the area of mathematical modeling and comparative studies of electrophysiological arrangement of atrioventricular connection and ventricular conduction system cells
Cm where V (t) is the voltage generated by a cardiac cell; Cm is the electric capacity; symbol I with different subscripts represents the concentration of relevant ions: INa is the sodium current, ICа,T, ICa,L are potassium currents T of L types, ICaP is the calcium pump, INaK is the Na, K pump, INaCa is the exchanger, If is the activated current, IB is the background current, and IK is the potassium current
Summary
The cardiac muscle comprises typical and atypical pacemaker cardiac cells which form the cardiac conduction system. Functional cardiac cells in the excited tissue state have the polarized membrane It has the positive charge on the outside and the negative one on the inside. Sodium ions enter a cell under the influence of any stimulus At this time the negative charge occurs on the cardiac cell membrane surface, and potential reversal is ensured. Cardiac muscle cells do not get excited by the further stimuli during the period of development of action potential This feature is essential for function of the heart as an organ. Cm where V (t) is the voltage generated by a cardiac cell; Cm is the electric capacity; symbol I with different subscripts represents the concentration of relevant ions: INa is the sodium current, ICа,T, ICa,L are potassium currents T of L types, ICaP is the calcium pump, INaK is the Na, K pump, INaCa is the exchanger, If is the activated current, IB is the background current, and IK is the potassium current. These dependencies are reflected in the model [12] which represents the partial differential system: Cp t
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