Abstract
Integrative genomic analysis reveals a conserved role for prolactin signalling in the regulation of adrenal function.
Highlights
To cite this version: Carmen Ruggiero, Barbara Altieri, Edith Arnold, Lourdes Siqueiros-Marquez, Mabrouka DoghmanBouguerra, et al
To get deeper insight into the mechanisms of age- and sexdependent adrenal function, we performed an integrative analysis of the mouse adrenal transcriptome by RNA-seq and active enhancer usage at different ages in both sexes
Expression of genes related to lipid metabolism and immunity was progressively enriched with age (Figure 1C and Supporting information Table S3), with the proportion of macrophages increasing and neutrophils/mast cells decreasing at older ages (Figure 1D)
Summary
To cite this version: Carmen Ruggiero, Barbara Altieri, Edith Arnold, Lourdes Siqueiros-Marquez, Mabrouka DoghmanBouguerra, et al. Dear Editor, We report here that the pituitary hormone prolactin (PRL) has an important, conserved role in regulating adrenal gland function. Multivariate analysis showed that age, but not sex, had a significant effect on adrenal global gene expression profiles (Figure and Supporting information S1; Tables S1, S2).
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