Abstract
Integrative framework Dyscovr links mutations within cancer drivers to downstream expression changesDyscovr uncovers known and novel targets of cancer-driver genesDyscovr reveals clinically important negative genetic interaction pairingsWeb platform to explore uncovered driver gene-target relationships. An integrative computational framework, Dyscovr, links mutated cancer driver genes to expression changes in putative target genes within and across 19 TCGA cancer types. Dyscovr's results include experimentally verifiable synthetic lethal driver-target pairings.
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