Abstract
Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. The origin of this movement disorder is poorly understood, although recent insights suggest involvement of disturbed force feedback. Assessment of sensorimotor integration may provide insight into the pathophysiology of fixed dystonia. Sensory weighting is the process of integrating and weighting sensory feedback channels in the central nervous system to improve the state estimate. It was hypothesized that patients with CRPS-related dystonia bias sensory weighting of force and position toward position due to the unreliability of force feedback. The current study provides experimental evidence for dysfunctional sensory integration in fixed dystonia, showing that CRPS-patients with fixed dystonia weight force and position feedback differently than controls do. The study shows reduced force feedback weights in CRPS-patients with fixed dystonia, making it the first to demonstrate disturbed integration of force feedback in fixed dystonia, an important step towards understanding the pathophysiology of fixed dystonia.
Highlights
Humans use proprioception, vision and the sense of touch to effectively handle objects with a wide range of mechanical properties
The results show that the force difference was greater in Complex regional pain syndrome (CRPS)-patients with fixed dystonia than in controls (p,0.05)
Our findings suggest that CRPS-patients did not optimally weight the sensory inputs
Summary
Vision and the sense of touch to effectively handle objects with a wide range of mechanical properties. The difference in force (DF) between the blind trials and the catch trials revealed the sensory weighting between force and position feedback. ANOVA’s were performed to test for an effect of group on the force difference between the blind and the catch trials (DF) and the sensory weights.
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