Abstract
T cell receptor (TCR) engagement by antigen presentation results in a stable contact between the T cell and the target cell known as the immunological synapse. Several types of receptor and effector proteins are dynamically organized at the synapse platform to tightly regulate T cell responses to the contact. Interleukin-2 (IL-2) is an essential signal for the proper T cell activation and expansion following antigen presentation. Polarization of IL-2R signalling to the synaptic cleft enhances STAT5 signalling, and trans-presentation of IL-2 at the synapse confers high-affinity IL-2 signalling that promotes priming of naive T cells.
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