Abstract

This paper presents a method for utilizing three-dimensional microfluidic channels fully to realize multiple functions in a single device. The final device structure was achieved by combining three independent modules that consisted of horizontal and vertical channels. The device allowed for the one-step generation of water-in-oil-in-water droplets without the need for partial treatment of the polydimethylsiloxane channel surface using separate modules for generating water-in-oil droplets on the horizontal plane and oil-in-water droplets on the vertical plane. The second vertically structured module provided an efficient flow for the generation of highly wettable liquid droplets, and tuning of the first horizontally structured module enabled different modes of inner-core encapsulation within the oil shell. The successful integration of the vertical and horizontal channels for core-shell droplet generation and the chemical synthesis of a metal complex within the droplets were evaluated. The proposed approach of integrating independent modules will expand and enhance the functions of microfluidic platforms.

Highlights

  • Chemical reactions or synthesis are critically influenced by environmental factors, where the mixing method or atmospheric conditions can affect the reaction’s speed results and efficiency [1,2,3]

  • Droplet-based microfluidic research has developed with the fields of chemistry and biology [6,7,8,9,10]

  • We showed the utility of a droplet generation module formed by a structure that can be integrated with other elements

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Summary

Introduction

Chemical reactions or synthesis are critically influenced by environmental factors, where the mixing method or atmospheric conditions can affect the reaction’s speed results and efficiency [1,2,3]. Multiphase core-shell droplets have been generated by various methods. The channel materials and structures only serve as a droplet generator and have low precision.

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