Abstract
Thermostable glycolipoprotein was isolated and purified from rat liver cytoplasm. The glycolipoprotein in small concentrations causes the increase in the maximum amount of calcium ions, which can be accumulated in rat liver mitochondria. Glycolipoprotein activity in cytoplasm is increased by insulin injection. The amino acid composition of ICR (insulin-dependent cytoplasmic regulator) differs from the amino acid composition of insulin. ICR inhibits the transport of oxidized substrates in mitochondria. The ICR introduction results in a great reduction in blood sugar in rats with alloxan diabet. The ICR also inhibits glucose output from the liver slices. It is supposed that the ICR is a mediator of insulin action on the liver metabolism.
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