Abstract
Insulin and the critically ill.
Highlights
Septic shock is the most common cause of death in intensive care units
In a prospective, randomized, controlled study involving adults admitted to surgical intensive care units and receiving mechanical ventilation [2], intensive insulin therapy substantially reduced mortality and morbidity
I was the first to suggest that the beneficial action of insulin in patients with acute myocardial infarction, especially those who are poor candidates for thrombolytic therapy and in whom the risk of bleeding is high, can be ascribed to its ability to suppress the production and harmful actions of tumor necrosis factor-α, macrophage migration inhibitory factor, and free radicals [1,4,5]
Summary
Septic shock is the most common cause of death in intensive care units. In the USA alone, more than 100,000 deaths occur as a result of septicemia and septic shock per year (for review [1]). A significant decrease in the concentrations of plasma soluble intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and plasminogen activator inhibitor-1 was noted in those obese persons after insulin administration. These actions of insulin and glucose on various parameters associated with inflammation are interesting in light of the relationship between human leukocyte antigen (HLA)-DR and CD11b expression, free radical generation, and development and recovery from postoperative or post-trauma sepsis [1,9,10].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
