Inspiratory Muscle Exercise Reduces Lipoperoxidation in Obese and Healthy Subjects: A Pilot Study

Abstract

IntroductionHigh‐intensity inspiratory exercise seems to increase oxidative stress in healthy subjects. Although obesity is related to impaired inspiratory muscle function, the acute effects of the inspiratory exercise remain unclear in obese subjects.MethodsWe studied 10 obese (35 ± 3 kg/m2; 32 ± 6 years old) and 10 healthy subjects (23 ± 2 kg/m2; 24 ± 5 years old). Maximal inspiratory pressure (PImax) was assessed by a pressure transducer. Blood sample was collected to assess thiobarbituric acid reactive substances (T‐BARS) before and after the inspiratory exercise performed in different days to inspiratory exercise without load maintained for 30 min, inspiratory exercise at 30% PImax maintained for 30 min and inspiratory exercise at 60% PImax maintained until reach the fatigue.ResultsInspiratory muscle strength was similar in obese and healthy subjects. Inspiratory exercise performed at 60% PImax reduced T‐BARS in obese (from 6 ± 2 nmol MDA/mL to 4 ± 2 nmol MDA/mL) and in healthy subjects (from 7 ± 4 nmol MDA/mL to 5 ± 3 nmol MDA/mL, ANOVA: Time= 0,003; Group= 0,52; Interaction= 0,98). As expected, inspiratory exercise performed without load and at 30% PImax did not change T‐BARS in obese and healthy subjects.ConclusionThis study shows that acute inspiratory exercise may reduce lipoperoxidation in humans.