Oxidative Stress in Healthy Subjects with Cardiometabolic Risk Factors

Abstract

WHO estimates that cardiometabolic diseases cause about 30% of deaths worldwide, Mexico is the second country with overweight/obesity. The presence of oxidative stress in healthy patients with cardiometabolic risk factors is poorly understood; therefore, the aim of this work was to determine the presence of oxidative stress in healthy subjects with cardiometabolic risk factors. The study was observational, descriptive, prospective, cross‐sectional with a sample of 49 healthy adult patients selected by non‐probabilistic sampling, medical history was evaluated and venous blood was obtained for plasma determination of carbonylated proteins.85.6% were female; the mean age was 40±11.1 years for women and 43.1±7.2 years for men. Lack of exercise was found in 53.1%, 25% were smokers, 96% had no diagnosis of diabetes mellitus or hypertension; 73.4% had a diagnosis of overweight/obesity. Cardiometabolic risk is present due to high waist circumference in 79.6%, and waist/hip ratio in 63%. Mean systolic blood pressure (SBP) was 116.98±12.01 mmHg and diastolic (DBP) was 74.63±10.66 mmHg. Carbonylated protein concentration in plasma was 0.457±0.025 nmol/mg of proteins. We found positive Pearson Correlations between: a) SBP/DBP and BMI diagnosis (0.399, p<0.017), age (0.035, p<0.035) and sex (0.362, p<0.010); and b) BMI with carbonylated proteins (0.376, p<0.008). Healthy subjects have high cardiometabolic risk in the presence of carbonylated proteins, associated with BMI. It is therefore important to reduce these risk factors and thereby prevent comorbidities.