Abstract
It has been shown that polyene antimycotics are selective according to the sterol present in the membrane, leading to stronger activity in fungal cells. However, it is not clear the role of the membrane structure in ionophoretic activity. In recent years, there has been a debate about if the homogenous model of the membrane is accurate or there exist nanoscopic domains enriched with sphingomyelin and cholesterol. The influence of sterol and its interaction with sphingomyelin can provide information on ordered domain formation.
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