Insights into the selective anticancer activity of [SnIV(L)(Cl)2(OH2)] [L =(E)-N,N-diethyl-2-(2-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide] at thiosemicarbazone appended tin(IV) site

Abstract

We herein report the synthesis of a mononuclear tin(IV) complex [SnIV(L)(Cl)2(OH2)] [L = (E)-N,N-diethyl-2-(2-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide] (1). From the X-ray crystallographic characterization the molecular geometry of 1 around Sn(IV) center has been found to be distorted octahedron. The present report illustrates the selective reactivity of 1 against human lung carcinoma epithelial cell line, A549 by inducing depolarization of the mitochondrial membrane potential resulting in selective cancer cell death.