Abstract
The study was aimed to investigate the hepato-protective effect of Moringa oleifera in Nile tilapia (Oreochromis niloticus) exposed to acetaminophen. Fishes exposed to sub-lethal concentration of acetaminophen for 96 hours, were fed on feed incorporated with moringa leaf, for 21 days. Histological studies of liver of fish fed with M. oleifera leaf incorporated feed , for 21 days after 96-hour acetaminophen exposure showed significant reparative changes when compared to the control. The experiment indicate that dietary supplementation of moringa leaf had hepatoprotective effect in Nile tilapia exposed to acetaminophen.
Highlights
The study was aimed to investigate the hepato-protective effect of Moringa oleifera in Nile tilapia (Oreochromis niloticus) exposed to acetaminophen
Hepatocytes were located among sinusoids and arranged as cords (Fig.1A) Generally healthy teleost fish showed normal architecture with a typical parenchymatous appearance without pathological abnormalities (Vicentini et al, 2005; Figueiredo et al, 2007)
Degeneration of hepatocytes, nuclear pyknosis in most cells and accumulation of metal binding proteins in its nuclei were reported in the liver of cadmium treated O. niloticus (Kaoud et al, 2011)
Summary
The study was aimed to investigate the hepato-protective effect of Moringa oleifera in Nile tilapia (Oreochromis niloticus) exposed to acetaminophen. Fishes exposed to sub-lethal concentration of acetaminophen for 96 hours, were fed on feed incorporated with moringa leaf, for 21 days. Histological studies of liver of fish fed with M. oleifera leaf incorporated feed , for 21 days after 96-hour acetaminophen exposure showed significant reparative changes when compared to the control. The experiment indicate that dietary supplementation of moringa leaf had hepatoprotective effect in Nile tilapia exposed to acetaminophen. Commonly known as drum-stick, is found mostly in Asia, Africa and South America. It is known as miracle tree due to its medicinal properties. The main objective of this study was to examine the ameliorative and hepatoprotective effect of M.oleifera leaves in acetaminophen induced toxicity in Nile tilapia
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