Abstract
Neuromedin U (NMU) is a regulatory peptide that is widely distributed throughout the body and performs a variety of physiological functions through its corresponding receptors. In recent years, NMU has become the focus of attention in various fields of research as its diverse and essential functions have gradually been elucidated. However, there have been no bibliometrics studies on the development trend and knowledge structure of NMU research. Therefore, in this study, we used VOSviewer software to statistically analyze scientific data from articles related to NMU to track the developmental footprint of this research field, including relevant countries, institutions, authors, and keywords. We retrieved a total of 338 papers related to NMU, written by 1,661 authors from 438 organizations of 41 countries that were published in 332 journals. The first study on NMU was reported by a group in Japan in 1985. Subsequently, nine articles on NMU were published from 1987 to 2006. A small leap in this field could be detected in 2009, with 30 articles published worldwide. Among the various countries in which this research has been performed, Japan and the United States have made the most outstanding contributions. Miyazato M, Kangawa K, and Mori K from the Department of Biochemistry, National Retrain and Cardiovascular Center Research Institute in Japan were the most productive authors who have the highest number of citations. Keyword analysis showed six clusters: central-nervous-system, homeostasis, energy metabolism, cancer, immune inflammation, and food intake. The three most highly cited articles were associated with inflammation. Overall, this study demonstrates the research trends and future directions of NMU, providing an objective description of the contributions in this field along with reference value for future research.
Highlights
Neuromedin U (NMU) is acknowledged as a highly conserved sequence neuropeptide which is a member of the neuroprotein family
Global NMU Publications Over Time A total of 338 documents related to NMU were retrieved, including 242 research articles (71.6%), 49 reviews (14.5%), and 34 conference abstracts (10.1%; Table 1); three of the articles were published in Japanese and the rest were in English
Bibliometric analysis revealed that most NMU research to date has been basic research, and these published articles mainly focus on animal experiments and review articles, as well as a few reports on clinical trials
Summary
Neuromedin U (NMU) is acknowledged as a highly conserved sequence neuropeptide which is a member of the neuroprotein family. Neuromedin U is secreted by different types of neurons (e.g., cholinergic, non-cholinergic, and sensory neurons), as well as by non-neuronal cells, including high expression in antigen-presenting cells (e.g., dendritic cells and monocytes) and other immune cells (e.g., B cells) [2]. A Bibliometric of Neuromedin U (including the testis, ovary, thyroid, spleen, placenta, and adipose tissue) and cell types (endothelial cells, keratinocytes, and lymphocytes), but is especially concentrated in the pituitary gland and gastrointestinal tract [3, 4] (Figure 1). Bibliometrics is used to statistically evaluate the scientific research achievements in a biomedical field, and to develop clinical practice guidelines and analyze research trends related to diseases [10].
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