Abstract
Neuromedin U,first isolated from porcine spinal cord,is widely distributed with highest expression in the gastrointestinal tract and the central nervous system.Its receptors are the endogenous ligands for two G protein-coupled receptors,FM-3 (neuromedin U receptor 1) and FM-4 (neuromedin U receptor 2).Recently,neuromedin U is found to be as an endogenous anorexigenic peptide.It can inhibit food intake,increase the locomotor activity,promote the metabolism of the body and regulate energy homeostasis.This review mainly introduces the roles of neuromedin U and its two receptors in regulation of food intake. Key words: Neuromedin U; Neuromedin U receptor 2; Food intake
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