Insights into the mechanisms involved in the exercise-enhanced white muscle growth in adult zebrafish Danio rerio

Abstract

Event Abstract Back to Event Insights into the mechanisms involved in the exercise-enhanced white muscle growth in adult zebrafish Danio rerio Mireia Rovira1*, Arjan Palstra1 and Josep Planas1 1 University of Barcelona, Departament of Physiology, Spain Exercise stimulates growth in salmonids but a very limited amount of information is available on the mechanism(s) by which exercise potentiates growth. Recently, we have investigated the potential of adult zebrafish to serve as a model for exercise-induced muscle growth. Therefore the optimal swimming speed at which zebrafish swims most efficient was quantified and applied in a long-term swimming experiment with zebrafish (n=83) swimming for 6h/day for 5 days/week over a 4 week period for comparison with zebrafish (n=83) that rested. For the first time a highly significant exercise-induced growth was demonstrated in adult zebrafish. Zebrafish that swam increased their total body length by 5.6% and body weight by 41.1% as compared to resting fish, comparable or even higher than reported for adult salmonid fish. The main aim of the present study is to provide insights into the mechanisms involved in exercise-induced muscle growth. White muscle gene expression was examined by investigating the effects of exercise on the expression of marker genes involved in muscle development, proliferation and differentiation under regulation of myogenic factors. The long-term swimming experiment was repeated to raise samples for histological analysis of muscle fiber size, number and area to quantify and qualify changes in muscle development (hypertrophy and/or hyperplasia). We show that zebrafish can be used as a vertebrate exercise model for enhanced growth, with implications in both basic, biomedical and applied sciences, such as aquaculture. Keywords: comparative endocrinology Conference: 25th Conference of the European Comparative Endocrinologists, Pécs, Hungary, 31 Aug - 4 Sep, 2010. Presentation Type: Conference Presentation Topic: Comparative endocrinology Citation: Rovira M, Palstra A and Planas J (2010). Insights into the mechanisms involved in the exercise-enhanced white muscle growth in adult zebrafish Danio rerio. Front. Endocrinol. Conference Abstract: 25th Conference of the European Comparative Endocrinologists. doi: 10.3389/conf.fendo.2010.01.00029 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Aug 2010; Published Online: 29 Aug 2010. * Correspondence: Dr. Mireia Rovira, University of Barcelona, Departament of Physiology, Barcelona, Spain, Mireira.rovira2@gmail.com.null Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mireia Rovira Arjan Palstra Josep Planas Google Mireia Rovira Arjan Palstra Josep Planas Google Scholar Mireia Rovira Arjan Palstra Josep Planas PubMed Mireia Rovira Arjan Palstra Josep Planas Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.