Abstract
Multidrug resistant bacteria are a serious worldwide problem, especially carbapenem-resistant Enterobacteriaceae (such as Klebsiella pneumoniae and Escherichia coli), Acinetobacter baumannii and Pseudomonas aeruginosa. Since the emergence of extensive and pan-drug resistant bacteria there are few antibiotics left to treat patients, thus novel RNA-based strategies are being considered. Here, we examine the current situation of different non-coding RNAs found in bacteria as well as their function and potential application as antimicrobial agents. Furthermore, we discuss the factors that may contribute in the efficient development of RNA-based drugs, the limitations for their implementation and the use of nanocarriers for delivery.
Highlights
In the year 2014, the World Health Organization reported the critical problem of antibiotic resistant bacteria (World Health Organization [WHO], 2014)
This review examines the current situation of non-coding RNA elements as antimicrobial agents and discusses some strategies and limitations for their implementation
The development of alternative strategies to battle bacterial pathogens are of outmost importance
Summary
Multidrug resistant bacteria are a serious worldwide problem, especially carbapenemresistant Enterobacteriaceae (such as Klebsiella pneumoniae and Escherichia coli), Acinetobacter baumannii and Pseudomonas aeruginosa. Since the emergence of extensive and pan-drug resistant bacteria there are few antibiotics left to treat patients, novel RNA-based strategies are being considered. We examine the current situation of different non-coding RNAs found in bacteria as well as their function and potential application as antimicrobial agents. We discuss the factors that may contribute in the efficient development of RNA-based drugs, the limitations for their implementation and the use of nanocarriers for delivery
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