Abstract
Objective: The methanolic leaf extract of Ventilago maderaspatana (MEVML, 200 mg/kg body weight [b.w.]) was investigate to hepatoprotective activity under streptozotocin-induced (45 mg/kg b.w.) diabetic (Di) rats.
 Methods: In the present study, we determined the blood glucose levels, b.w., insulin, creatinine, and bilirubin levels in normal, Di, Di treated with MEVML and positive control rats.
 Results: The Di rats shown adverse changes in blood glucose levels, b.w., insulin, creatinine, and bilirubin levels when compared to other group rats. Reverse the adverse changes in the above parameters when treated the Di rats with MEVML
 Conclusion: The MEVML shown anti-diabetic activity and reverse the adverse changes in the above parameters in liver so that the MEVML supported the traditional claim of the hepatoprotective activity under Di condition.
Highlights
Diabetes mellitus (DM) is a metabolic disorder, in which hyperglycemia was take place as result of lack of insulin or insulin resistance [1,2]
The blood glucose of normal control (NC) rats increased in 1 month treatment period; the blood glucose levels of Di control (DC) rats were significantly increased when compared with NC rats after injection with STZ
MEVML did not alter the blood glucose levels of compared to normal rats alone, while treated the Di rats with MEVML significantly decreased the blood glucose levels compared to DC rats
Summary
Diabetes mellitus (DM) is a metabolic disorder, in which hyperglycemia was take place as result of lack of insulin or insulin resistance [1,2]. Hyperglycemic condition for long period could generate a high amount of free radicals that can ensure diabetic (Di) complications by the malfunction or damage of insulin dependent organs [4,5]. Numbers of anti-diabetic drugs were used in the Di management, including biguanide, thiazolidinedione, and sulfonylurea. These drugs were restricted due to several considerable side effects that were raised when used these agents [10]. Ventilago maderaspatana is widely grown in South Greece, India, Indonesia, Myanmar, and Sri Lanka forests of low elevations. It is commonly known as a red creeper. The bark, root, leaf, hole plant, and other parts of different extracts of V. maderaspatana have shown different medicinal values such as antimicrobial activity, anti-Di activity, hepatoprotective, cardioprotective respectively [17,18,19,20]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
