Abstract
The goal of brain drug targeting technology is the delivery of therapeutics across the blood brain barrier (BBB), including the human BBB. Nose to brain drug delivery has received a great deal of attention as a non- invasive, convenient and reliable drug delivery system. For the systemic and targetedadministration of drug. The various drug deliveries through some drug transport pathways, Factor influencing nasal drug absorption, formulation strategies nose to brain, colloidal carriers in nose to brain drug delivery system and nasal delivery systems. Physiological barriers (BBB) that restricts the delivery of drug to CNS. Thus intranasal route has attracted a wide attention of convenient, non-invasive, reliable, and safe route to achieve faster and higher level of drug in the brain through olfactory region by passing blood brain barrier. Intranasal administration rapid onset of action, no first –pass effect , no gastrointestinal degradation lungs toxicity and non-invasiveness application and also improves bioavailability.
Highlights
The delivery of drug to the brain still remains problematic because of poor bioavailability due to the impervious nature of the endothelial membrane separating the central intestinal fluid and the systemic circulation from blood
The absorption and permeation of drug for desired therapeutic action in brain is restricted by the blood brain barrier (BBB)
Nasal Drug Delivery Route The nasal route has gained attention as it is a direct noninvasive way to transport drugs to the brain which cannot be transferred via the oral route
Summary
The delivery of drug to the brain still remains problematic because of poor bioavailability due to the impervious nature of the endothelial membrane separating the central intestinal fluid and the systemic circulation from blood (termed as Blood Brain Barrier-BBB). Scientists have focused their research toward intranasal administration for drug delivery to the brain especially for the treatment of CNS diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, anxiety, autism spectrum disorders, seizures, drug addiction, eating disorders, and stroke such as epilepsy, migraine, emesis, angina pectoris and erectile dysfunction.[1,2,3]. This is all the possible pathways for drug can reach brain after nasal administration is predominately either by the olfactory or trigeminal region or through systemic circulation as shown in-[4].
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