Abstract
This chapter focuses on the actors of knowledge, innovation and entrepreneurship, as comparative advantages towards regional sustainable development. The chapter describes the analytical framework in which technical change, innovation and entrepreneurship activities are considered as among the most important factors influencing sustainable economic development, both in national and regional level. Within this analytical framework, the chapter aims to provide a clear understudying of the main related questions summarized in the following: To which extent economic development depends on the presence of a network favorable to knowledge, innovation and entrepreneurship, based on the endogenous development capabilities? How could the level of regional innovation activities be enhanced? How could the effect of innovation activities on regional development be estimated? What is the relative position of a region as far as development and innovation competitiveness are concerned?
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