Abstract
IL-17, as a pro-inflammatory cytokine, is one of the early initiation factors of the inflammatory response induced by T cells.It can induce and regulate multiple immune responses.Recent studies have revealed that myeloid neutrophils, macrophage, mast cell and other innate immune cells all can secrete large amount of early responding IL-17 in organs suffering ischemia/hypoxia, and in turn can activate, amplify and recruit neutrophils to the reperfusion-damaged tissue to release large amount of free radicals and lysozyme that cause IRI.Researchers have also provided evidence that appropriate administration of anti-IL-17 mono-antibody to neutralize IL-17 during early reperfusion stage would reduce the tissue damage.The purpose of this review is to summarize the research progress of the effects of IL-17 produced by innate immunocyte on organ reperfusion injury. Key words: Innate Immune; IL-17; Ischemia Reperfusion Injury; Organ
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