Abstract
Objective:To observe the effect of intravenous infusion of immune globulin in the treatment of children with severe pneumonia.Methods:Ninety-eight children with severe pneumonia who received treatment in our hospital between April 2015 and December 2016 were selected, and they were grouped into a control group and an treatment group, 49 each group. The control group received conventional treatment. The treatment group was additionally treated with immune globulin on the basis of conventional treatment. The humoral immune indicators were detected using immunoturbidimetric assay, and the inflammatory reaction indicators were detected using enzyme-linked immunoabsorbent kit. The overall efficacy, clinical symptoms, humoral immunity and inflammatory response were compared between the two groups.Results:The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The cough, rale and fever of the treatment group disappeared faster than those of the control group, the relief of cardiac failure was also faster in the treatment group (P<0.05). The immunoglobulin G (Ig G), Ig A and Ig M of patients in the two groups compared before treatment, and no significant difference was found (P>0.05). The Ig G level of the treatment group was higher than that of the control group after treatment (P<0.05). The comparison of Ig A and Ig M between the two groups indicated no significant difference (P>0.05). The two groups had no significant differences in the content of tumor necrosis factor (TNF)-α, C-reactive protein (CRP), soluble intercellular adhesion molecule (SICAM)-1 and interferon (IFN)-γ (P>0.05) before treatment, but the content of the treatment group was significantly higher than that of the control group (P<0.01).Conclusion:Immunoglobulin was significantly effective in the adjuvant treatment of children with severe pneumonia, and it can rapidly improve the improvement of symptoms, enhance immune function and inhibit inflammatory reaction; therefore it is worth promotion.
Highlights
Severe pneumonia in children which is usually caused by respiratory syncytial virus infection can weaken the immune function of children; featured by acute onset and severe disease condition, it can lead to death if treatment is not performed timely.[3]
There was no significant difference in the levels of immunoglobulin G (Ig G), Ig A and Ig M between the two groups before treatment (P>0.05)
Changes of content of inflammatory factors: Before treatment, no differences were found in the content of tumor necrosis factor (TNF)-α, C-reactive protein (CRP), sICAM-1 and IFN-γ between the two groups (P
Summary
Severe pneumonia is a common emergency and severe respiratory disease in the department of pediatric internal medicine and a main cause for death of hospitalized infants in China.[1,2] Severe pneumonia in children which is usually caused by respiratory syncytial virus infection can weaken the immune function of children; featured by acute onset and severe disease condition, it can lead to death if treatment is not performed timely.[3] Severe pneumonia. Some studies have suggested that severe pneumonia in children is related to the disorder of immune function, and inhibition of humoral immune response and insufficient secretion of immunoglobulin (Ig) are important reasons for the development and poor prognosis of severe pneumonia.[7,8,9] Ig for intravenous injection is a blood product purified from a large number of healthy human plasma, and its main ingredient is protein. This study emphatically analyzed the efficacy of intravenous injection of Ig in the adjuvant treatment of children with severe pneumonia and its influence on humoral immunity and inflammatory state
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