Effects of Xingnaojing injection on PCT, CRP and WBC in elderly patients with severe pneumonia

Abstract

Objective To investigate the effect of Xingnaojing injection combined with ambroxol hydrochloride on precalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC) in the elderly patients with severe pneumonia, and to observe the clinical effect. Methods From December 2013 to March 2015, 94 cases of severe pneumonia in Zhejiang Quhua Hospital were selected and divided into treatment group and control group according to the random digital table method, with 47 cases in each group.The control group was treated with ambroxol hydrochloride, while the treatment group was treated with Xingnaojing injection on the basis of the control group.The main symptom scores, blood gas analysis indicators, PCT, CRP and WBC changes and therapeutic effects were compared between the two groups before and after treatment. Results After treatment, the fever score and cough score in the treatment group [(1.03±0.25)points, (1.12±0.29)points] were significanly lower than those in the control group [(2.17±0.42)points, (2.34±0.71)points] (t=15.989, 10.905, all P<0.05). After treatment, the PaO2 of the treatment group [(89.47±8.41)mmHg] was higher than that of the control group [(76.39±5.63)mmHg], while PaCO2 [(48.37±7.19)mmHg] was lower than that in the control group [(63.27±3.48)mmHg], the differences were statistically significant (t=8.860, 12.780, all P<0.05). After treatment, the serum levels of PCT, CRP and WBC in the treatment group were (5.41±0.97)ng/L, (48.98±8.97)mg/L, (7.82±1.23)×109/L, respectively, which were significanly lower than those in the control group [(7.98±1.47)ng/L, (76.45±12.54)mg/L and (12.56±1.89)×109/L] (t=10.004, 12.214, 14.410, all P<0.05). The total effective rate in the treatment group(91.49%) was higher than that in the control group (72.34%), and there was statistically significant difference (χ2=5.817, P<0.05). Conclusion Xingnaojing injection combined with ambroxol can reduce the changes of serum PCT, CRP and WBC in the elderly patients with severe pneumonia, and the curative effect is significant.It is worthy of clinical study. Key words: Pneumonia; Calcitonin; C-reactive protein; Leukocyte count; Xingnaojing injection; Ambroxol hydrochloride; Aged