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Abstract
Aim: A polymeric in situ gelling delivery system for localized and sustained delivery to jawbone infections was developed. Materials & methods:In situ gelling delivery systems were prepared using either Poly(dl-lactic acid)or chitosan and Pluronic F127/Pluronic F68. Metronidazole nanoparticles were prepared using poly(dl-lactide-co-glycolide)or chitosan. Poly(dl-lactide-co-glycolide) was used for microparticles. Particles were characterized for size, chargeand morphology. Results: Viscosity and yield stress of the gels were 0.4Pa.s and 2Pa, respectively, with 70% cell viability over 72h. Around 90% of loaded metronidazole was released at a sustained rate over 1 week. Conclusion: Use of appropriate amount of nano/microparticles in the gel resulted in a sustained release over a period of 1 week - needed for jawbone infection.
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