Initial research of serum glycated albumin during pregnancy

Abstract

To explore the normal range of serum glycated albumin (GA) during the second trimester in non-gestational diabetes mellitus (GDM) population and the value of serum GA in the blood glucose monitoring during pregnancy. The GA was measured in 101 healthy gravida during the second trimester and 80 gravida with GDM and diabetes mellitus who were in treatment at Peking University First Hospital between August 2011 and December 2011, in order to analyze the normal range of GA and the relationship between GA and the level of blood glucose. (1) The normal range of GA during the second trimester was 10.9%-15.3%, which was negatively correlated with body mass index (P < 0.01). (2) Significant correlations were observed between GA and the level of hemoglobin A1c (HbA1c), preprandial, postprandial and mean plasma glucose in gravida with GDM and diabetes mellitus (r:0.361, 0.252, 0.338, 0.310;all P < 0.05). (3) When the level of GA was 13.97%, the sensitivity and specificity index for glucose control were 78.0% and 74.4%. GA could evaluate the severity of disease in gravida with GDM and diabetes mellitus. 10.9%-15.3% could be suggested as normal range of GA for the gravida at the second trimester.