Abstract
The pharmacological effects of Musanga cecropioides on rat thoracic aorta were examined in high K,SUP>+ medium (55mM), Ca 2+ 3mM) induced vasoconstriction was inhibited by Musanga cecropioides in a concentration-dependent manner. The tonic contra ctions elicited by KCI 55mM were relaxed by Musanga and were more marked in 0.45mM Ca 2+ than 1.8mM Ca 2+ medium. NA -induced responses were antagonized non competitively by Musanga. NA- sustained contraction was relaxed, the relaxing effect of Musanga was not antagonized by indomethacin or methylene blue. It is concluded that Musanga relaxation of the rat aorta does not involve cyclo-oxygenase, nor cAMP pathway, but unique, unlike those of known classical vasodilators. African Journal of Biomedical Research Vol. 8(1) 2005: 59-61
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.