Abstract
The effect of tin on intestinal calcium absorption was studied in rats given stannous chloride (Sn, 30 mg/kg every 12 hr) orally for 3 days. The increase of serum calcium concentration after a single oral administration of calcium chloride (Ca, 500 mg/kg) was significantly inhibited by the prior administration of tin. Calcium concentrations in duodenal mucosa were also reduced to one-third of control values by the administration of tin. The calcium-binding activity in the supernatant fraction of 38,000 g of the mucosal homogenate was decreased to one-quarter of control values, and alkaline phosphatase activity in the mucosal homogenate was markedly lowered by the administration of tin. These results suggest that the oral administration of tin inhibited the duodenal active transport of calcium.
Published Version
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