Abstract
A pituitary factor decreasing iodine uptake and protein-bound iodine formation in human leukocytes was found in semi-purified preparations of TSH, LH, FSH, GH and in crude anterior pituitary extract. ACTH, insulin, serum gamma globulin, myoglobin and ceruloplasmin were ineffective in comparison to control samples incubated with serum albumin. TSH, in relation to dose (0.01–0.5 U/ml), significantly decreased the total uptake, formation, and release of iodocompounds from phagocytic leukocytes. The amount of iodocompounds released from resting or phagocytic leukocytes into the media was twice as high as the amount of organically bound iodine that remained in the cells. These data suggest that iodine-containing compounds are actively formed, metabolized, and released from human leukocytes. Because TSH also decreases engulfment of latex microparticles, the observed changes in iodine metabolism are probably secondary, due to the reduced phagocytosis. The presence of an unknown factor in the semipurified prepara...
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