Abstract
Some surveys have shown the possibility of controlling the growth of cancer cells by decreasing the content of 2OGoxygenase with NOG. This research aims to supply the blank of whether the anti-cancer ability of NOG exists in vitroand xenografted mice and how this ability is formed. Use human gastric cancer cell lines, SGC7901. They have broughtNOG, MTT, and cisplatin from different companies separately. Choose 60 male BALB/c Nude mice aged four weekswith an average weight of 15 – 20g as the experimental subject. Measure killing by MTT assay and tumor shrinkagein an SGC-7901 xenograft mouse and 2OG oxygenase by western blot. The possible results are: (1) NOG restrainsSGC7901 cells’ growth by inhibiting the abundance of 2OG oxygenase. (2) NOG can restrain the growth of SGC7901cells, but the principle differs from inhibiting the abundance of 2OG oxygenase. (3) NOG cannot restrain the growth ofSGC7901 cells.
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