Abstract
Hemin and chlorophyllin are known to inhibit strongly the mutagenicity of benzo[ a]pyrene in the Salmonella assay. To further investigate this phenomenon, a series of these pyrrole pigments including pure samples of Cu- and Fe-chlorins were tested for their potency to inhibit the mutagenicity of benzo[ a]pyrene and its metabolites, benzo[ a]pyrene-7,8-diol, benzo[ a]pyrene4,5-epoxide, and benzo[ a]pyrene-7,8-diol-9,10-epoxide. Hemin was the most potent amongthe pigments tested for these inhibitions. Both hemin and Cu-chlorin accelerated efficiently the degradation of benzo[ a]pyrene-7,8-diol-9,10-epoxide, and this acceleration seemed to be the predominant mechanism by which these pigments inhibit the overall mutagenicity of benzo[ a]pyrene in Salmonella. Based on spectroscopic evidence, we speculate that a complex formation between hemin and benzo[ a]pyrene-7,8-diol-9,10-epoxide takes place and that this complexing is the cause of the accelerated degradation.
Published Version
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