Abstract
Inoculation of the chorioallantoic membrane (CAM) of fertile chicken eggs with Coxsackie virus 24 hours prior to inoculation with Rous sarcoma virus resulted in about a fourfold decrease of the number of pocks formed by Rous sarcoma virus. The size and number of occasionally occurring gross tumors were also considerably reduced. On the other hand, the decrease of the number of pocks caused by ultraviolet-irradiated Coxsackie virus was negligible. However, the size and number of gross tumors were reduced to the same degree as by active Coxsackie virus. Ultraviolet-irradiated influenza virus caused about a tenfold, and interferon about a fivefold, decrease of the number of pocks formed by Rous sarcoma virus and also a considerable reduction of size and number of gross tumors. In control experiments with Semliki Forest virus as the challenge virus in plaque assays, interference was obtained with active Coxsackie virus, ultraviolet-irradiated influenza virus, and interferon. Coxsackie virus did not in any of the systems used produce measurable amounts of interferon or interferon-like substances and the mechanism of the interference between Coxsackie virus and Rous sarcoma virus remains open. In the case of influenza virus the interference phenomenon described is apparently due to production of interferon on the CAM.
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