Abstract
The inhibitory actions of polyphloretin phosphate (PPP) and related compounds,di-4-phloretin phosphate(DPP), phloretin and trihydroxy propiophenone(THPP) on the contractile responses to prostaglandin(PG) and acetylcholine (ACh) in longitudinal smooth muscle of guinea-pig stomach were studied. Of the four inhibitors PPP and DPP showed relatively selective antagonism for PGE 1. DPP gave the highest pW 2 value against PGE 1. These results indicate that DPP is a useful antagonist of PG in smooth muscle, although it slightly inhibits responses to ACh,5-HT or histamine, and the Ca-induced contracture in K depolarized preparation.
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