Abstract
In the longitudinal smooth muscle of guinea-pig stomach, verapamil (10(-5) M) which showed marked suppression of high K-induced contractures, did not suppress the contractile response to PGE1 (1.5 X 10(-9) to 10(-6) M) markedly. These results suggest that the contractile mechanism of PGE1 in guinea-pig stomach may mainly depend on a release of bound Ca in the cell and partly depend on a Ca influx from the extracellular origin.
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