Abstract
Inhibition of aromatase activity in human placental microsomes with 3-deoxy-(1, 2, 4, 6 and 8), 6-oxo-(3, 5 and 9), and 16α-bromo- (7) steroids was studied using [1β- 3H]16α- hydroxyandrostenedione (16α-OHAD) as a substrate and compared to that with the conventional substrate, [1β- 3H]androstenedione. All the steroids inhibited both 16α-OHAD and [1β- 3H]androstenedione aromatization in a competitive manner. Based on K i / K m ratios obtained in both series of experiments, their relative inhibitory activities in the series with 16α-OHAD were not necessarily identical with those in the other series. The results would be important to understand the relationship of structure to function of aromatase in human placental microsomes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Steroid Biochemistry and Molecular Biology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
