Abstract
Vascular myocytes express two groups of functional canonical transient receptor (TRPC) channels, which we have termed TRPC1 for TRPC1-containing and TRPC3/6/7 for non-TRPC1 containing channels. These two groups have distinct properties from each other, for example, TRPC1 channels have a single unitary conductance of 2-3 pS and require PIP2 and PKC for activation, whereas TRPC3/6/7 channels have multiple conductances between 10-70 pS and are inhibited by PIP2 and PKC. The present work investigated interactions between TRPC1/C5 and TRPC6 channels activities evoked by angiotensin II (Ang II) in freshly isolated rabbit mesenteric artery myocytes.
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