Abstract
Cycloheximide (CH) and puromycin (PM) strongly antagonize induction of sister-chromatid exchanges (SCEs) by exogenous agents regardless of the mechanisms for initiating damage. 5-Bromodeoxyuridine (BUdR) substitution was used to monitor SCEs, but the background level of BUdR-induced SCEs was unaffected by the presence of protein inhibitors. Antagonism between DNA-damaging agents and protein inhibitors was strongest in euchromatic regions. Possible relationships between SCE formation and the mechanism of antagonism by protein inhibitors are discussed.
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