Abstract
Background: Metal coordination complexes of polyphenolic compounds have been claimed to have better antioxidant and protection against protein oxidative damage effects than the isolated ligands. Whereas flavonoids have been extensively studied, xanthones such as mangiferin are lacking extensive research. Methods: Cu (II), Zn (II), and Se (IV) mangiferin complexes were synthesized with different stoichiometric ratios. Products were isolated by preparative chromatography and subjected to spectral analysis by FT-IR, HPLC-DAD, and HPLC-ESI-MS. The inhibition effects on peroxidation potential and protein oxidative damage were determined for all the metal–MF complexes. Results: Eight metal–MF complexes were isolated. Cu (II)–MF complexes did not improve MF antioxidant/protective effects; Zn (II) complexes (stoichiometric ratio 1:2) antioxidant/protective effects had no significant differences to MF; Zn (II)– and Se (IV)–MF complexes (stoichiometric ratio 1:3) showed the best inhibition effects on peroxidation potential (49.06% and 32.08%, respectively), and on the protection against protein oxidative damage (14.49% and 20.81%, respectively). Conclusions: The antioxidant/protective effects of Se (IV)– and Zn (II)–MF coordination complexes were significantly improved as compared to isolated MF, when the reaction between the metal salt and MF was performed with a stoichiometric ratio 1:3.
Highlights
Studies about the possible therapeutical application of coordination complexes with bioactive organic ligands have demonstrated exceptional development in the first two decades of the 21st Century
We investigated the presence of copper (II), zinc (II), and selenium (IV) in several varieties of mango trees and found that Se concentration was consistent among the varieties while Cu and Zn concentrations varied according to the mango variety [18]
Spectral characterization, and evaluation of the peroxidation potential and protection against protein oxidative damage of MF metal complexes with Cu (II), Zn (II), and Se (IV) for the first time to demonstrate the possibility to develop new compounds with the capability to increase the antioxidant effect and protection against protein oxidative damage as compared to the isolated ligand (MF)
Summary
Studies about the possible therapeutical application of coordination complexes with bioactive organic ligands have demonstrated exceptional development in the first two decades of the 21st Century. Transition metals seems to be interesting because of the broad spectrum of complex geometries, coordination numbers, and redox states as compared to other metal groups Redox activities of these complexes and their influence on the homeostasis at the cellular level have been intensively investigated because of their antioxidant and protection against protein oxidative damage properties [1]. Spectral characterization, and evaluation of the peroxidation potential and protection against protein oxidative damage of MF metal complexes with Cu (II), Zn (II), and Se (IV) for the first time to demonstrate the possibility to develop new compounds with the capability to increase the antioxidant effect and protection against protein oxidative damage as compared to the isolated ligand (MF). Metal coordination complexes of polyphenolic compounds have been claimed to have better antioxidant and protection against protein oxidative damage effects than the isolated ligands.
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