Abstract
Background and Aims : PCSK9, beyond regulating plasma cholesterol levels, exerts several pleiotropic effects modulating lipid metabolism in extrahepatic cells, including macrophages. Macrophage cholesterol homeostasis strictly depends on serum lipoprotein functions, including the HDL capacity to promote cell cholesterol efflux (cholesterol efflux capacity, CEC) and the serum capacity to promote cell cholesterol accumulation (cholesterol loading capacity, CLC). The aim of the present study was to evaluate potential changes in HDL-CEC and serum CLC after six-month of treatment with PCSK9 inhibitors in Familial Hypercholesterolemia (FH) subjects.
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