Abstract
Treatment with Ca++ ionophore A23187 blocks biosynthesis of the major terminally (IV3)sialylated higher species of neuronal gangliosides: GD1A, GT1B, GQ1B, and GP, key components in the plasma membrane of neurite-bearing neurons. At the same time, the neurital field diminishes markedly, resulting in neuronal reversion to pre-neuritogenic morphology. A23187 causes no biosynthetic loss of any of the simpler gangliosides that constitute the plasma membrane of pre-neuritogenic neurons, nor of ganglioside precursors leading to formation of the blocked gangliosides. The data indicate that A23187 significantly reduces neuritogenic ganglioside biosynthesis.
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