Inhibition of <i>Staphylococcus aureus ATCC</i> and <i>Aspergillus niger</i> by Extracts of <i>Terminalia neotaliala capuron </i>(Combretaceae), Compared to Oxacillin and Fluconazole

Abstract

Therapy by synthetic antimicrobial drugs is increasingly becoming limited by microbial resistance. As a possible remedy, antimicrobials from medicinal plants are being explored. The objective of this work was to compare the activities of extracts of Terminalia neotaliala capuron, oxacillin, and fluconazole on the in vitro growth of Staphylococcus aureus ATCC and Aspergillus niger. The evaluation was made by incorporating the hydroalcoholic extract of the plant (Combretaceae), oxacillin, and fluconazole using the oblique double dilution method with Sabouraud agar into wells cut into Petrie dishes. After 48 hours of incubation at 30⁰ C, zones of inhibition were measured. Oxacillin had a greater zone of inhibition than the plant extract on Staphylococcus aureus ATCC for all concentrations. The zone of inhibition for fluconazole was lower than that of the extract on Aspergillus niger for the concentrations of 200 mg/mL and 100 mg/mL. The hydroethanolic extract of Terminalia neotaliala capuron inhibited the growth of Staphylococcus aureus ATCC and Aspergillus niger.