Abstract
Abstract The effects of different samples of cetrimide on the intestinal absorption of D-glucose, sodium butyrate and DL-methionine were compared with those of homologous compounds C(10)-C(20) of the same alkyl series, by in vivo intraluminal perfusion in the mouse, rat and guinea-pig. Two samples of “cetrimide” had different inhibitory activities in the mouse and rat but were equiactive in the guinea-pig in which both samples caused glucose reversal. None of the homologues, C(10)-C(20), paralleled the activity of either of the cetrimide samples exactly. It is concluded that cetrimide should be assayed in the rat before its use in studies of absorption and protein binding.
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