Abstract
Most tumor cells attain their immortality by reactivating telomerase. We report here the telomerase inhibitory potential of chimeric oligonucleotides composed of a 13mer antisense sequence targeting the telomerase RNA template region and a (s 4dU) n moiety at its 3′ or 5′-end. The increase of the thiolated chain length enhances the telomerase inhibitory potential, but decreases specificity, indicated by HIV reverse transcriptase inhibition. Chimeras with 5′ (s 4dU) n s were more potent inhibitors than the antisense alone or the 3′ modified ones. Cy5-labeled (s 4dU) 4AS and (s 4dU) 8AS proved the internalization of the oligonucleotides, raising the possibility to be tested as cellular anti-telomerase agents.
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