Abstract
The percentage fertilization of eggs of the urchin Parechinus angulosus (Leske), following exposure of the sperm to a variety of organic pollutants, was used to test the possibility of predicting toxicities from a consideration of molecular structure. A correlation is demonstrated between concentrations resulting in 50-per-cent inhibition of fertilization (EC 50 or FID 50) and the zero, first-order and second-order molecular-valence connectivity indices of the substances concerned. This correlation is more marked when a series of alcohols rather than a variety of non-alcoholic substances is used. A log or power expression best describes the relationship.
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