Inhibition of experimentally-induced gastric ulcers in the rat by a new sulfated glycopeptide

Abstract

A sulfated glycopeptide (GLPS) obtained by sulfonation of a glycopeptide derived from pig duodenum was tested as an inhibitor of experimental gastric ulcers in rat. GLPS, given orally, (15–190 mg/kg) protected the rats against gastric ulceration induced by pyloric ligation or by administration of hypertonic glucose to fasting rats; after oral administration (10–25 mg/kg) it was active against hydrocortisone and restraint-induced ulcers. A protective effect of GLPS against Shay ulcers was also demonstrated after intraperitoneal or intravenous administration. A dose-response relationship was always found except for restraint ulcers. In pyloric-ligated rats GLPS revealed a strong anti-peptic activity and an inhibitory effect on gastric secretion when given orally. The latter effect was also seen after intravenous administration. On the basis of its anti-peptic and anti-secretory activity, an explanation of the protectice effect of GLPS against gastric ulceration is presented.