The inhibition of gastric mucosal injury by <i>Chinnodbhavadi kwath</i> (decoction) - an Indian Ayurvedic formulation in rats

Abstract

Objective: As per ancient Indian text, one of the Triphala formulations called as Chinnodbhavadi kwath (decoction) is used for chronic hyperacidity and gastric problems. Triphala formulation is categorized as an Ayurvedic rejuvenator. The purpose of the present study is to evaluate the potential role of Chinnodbhavadi kwath in modulating the extent and severity of experimental gastric ulcer in rats to substantiate its traditional claim. Methods: Gastric ulcers were induced by aspirin (200 mg/kg, orally for three days) plus pyloric ligation in rats. The test drug was studied for its effect on ulcer index, secretory parameters, mucin activity in gastric juice and nucleic acid content in stomach homogenate of rats. Results: Chinnodbhavadi kwath (8.7 ml/kg) showed significant anti-ulcer activity. This activity depends mainly on significant decrease in intensity of gastric ulcers, inhibition of acid secretion and strengthening the mucosal defense system by increasing mucin secretion. The increase in nucleic acid content of gastric wall mucosa in drug treated groups indicate decreased cell shedding and increased life span of cells. Conclusion: Based on the data generated it is suggested that Chinnodbhavadi kwath provides significant protection in experimental gastric ulcer in rats. Conclusion: Based on the data generated it is suggested that Chinnodbhavadi kwath provides significant protection in experimental gastric ulcer in rats.