Abstract
The response of the isolated guinea pig ileum to angiotensin, bradykinin, eledoisin, and acetylcholine was studied before and during exposure to morin. Dose–response curves were made for each agonist in the presence of different concentrations of the flavonoid (1 to 8 μg/ml). Under these conditions, the responses of the ileum to eledoisin, angiotensin, and acetylcholine were modified to various degrees depending upon the concentration of morin. With morin 1 μg/ml, the effect of eledoisin was reduced, and the activity of this polypeptide progressively decreased with an increase in the concentration of the inhibitor. On the other hand, the activity of acetylcholine was potentiated while that of bradykinin and angiotensin was unchanged. With higher concentrations of morin (4 and 8 μg/ml), the effect of both angiotensin and acetylcholine was slightly reduced. On the rat blood pressure, morin did not modify the effect of agonists. From these results it is concluded that morin is a specific and noncompetitive inhibitor of eledoisin on the isolated guinea pig ileum.
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